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View ptab filed documents12/28/2023 ![]() 17 For institutions in IPR proceedings, the PTAB considers whether the petition (in view of the preliminary response) demonstrates a reasonable likelihood of unpatentability for at least one challenged claim. 16 In its institution decision, the PTAB must either institute review of all grounds presented in the petition or deny institution entirely. The PTAB has up to three months to issue a decision on whether to institute trial after the earlier of (1) the patent owner’s preliminary response filing, or (2) the preliminary response due date. 15 As a result, patent owners often reserve at least some substantive arguments concerning a disputed question of fact for presentation during the post-institution trial. ![]() 14 While the preliminary response may be supported by declarant testimony, such as testimony from an expert witness, at this early stage the PTAB views genuine factual disputes in the light most favorable to the petitioner. The patent owner has three months to file an optional patent owner preliminary response, which can address reasons why the Board should decline to institute review of the challenged patent. Once the petition is filed and accepted by the Office after a procedural review, a filing date is awarded. 12 Although the PTAB previously used a different claim construction standard than district courts, the PTAB now construes claims under the same “ Phillips” standard. 11 The petition must also set forth the petitioner’s positions on all necessary claim construction issues. 10 The PTAB requires a showing by a preponderance of the evidence, which is more favorable to petitioners than the clear and convincing evidence standard applied in district court. The petitioner bears the ultimate burden of proof for unpatentability in PTAB proceedings. 8 A notable restriction on the timing of IPR petitions is the “one-year bar,” which prohibits institution of an IPR petition filed more than one year after service of a district court complaint alleging infringement of the patent-at-issue. 7 Testimony supporting the petition must be submitted in the form of a written declaration, such as expert witness testimony regarding the knowledge of a skilled artisan. This petition must identify, with particularity, each claim challenged, the grounds on which each challenge to each claim is based, and the evidence supporting each ground. Pre-Institution FilingsĪ party initiates a post-grant proceeding at the PTAB by filing a petition for review. 5 CBM and PGR proceedings, in contrast, allow for a broader range of legal challenges, including grounds addressing subject matter eligibility, enablement, indefiniteness, and written description support. 4 Prior art asserted during an IPR is also limited to patents and printed publications. 3 IPR proceedings are limited to patent validity challenges under the legal theories of anticipation and obviousness. 1 The popularity of IPRs likely hinges, at least in part, on the proceeding’s relatively less restrictive provisions regarding which patents are eligible for review 2 and post-decision estoppel. To date, IPRs have been the most popular PTAB trial proceeding, comprising 93% of petitions filed at the PTAB through August 31, 2019. There are several types of adversarial post-grant proceedings at the PTAB, including inter partes review (IPR), covered business method review (CBM), and post-grant review (PGR). This paper presents a brief summary of key case milestones and strategic considerations for PTAB trials. These trials are relatively fast, inexpensive, and narrow in scope compared to litigation in other forums, such as district courts or the International Trade Commission. Since the passage of the America Invents Act in 2011, a significant proportion of patent litigation in the United States has moved to trials held before the Patent Trial and Appeal Board (PTAB) of the US Patent and Trademark Office (USPTO).
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Black and white faces drawing emman whatson12/28/2023 Rowling adds that Hermione's parents, two Muggle dentists, are a bit bemused by their odd daughter but "quite proud of her all the same". ![]() She is an overachiever who excels academically and is described by Rowling as a "very logical, upright and good" character. Rowling states that she was born on 19 September 1979 and she was nearly twelve when she first attended Hogwarts. ![]() Hermione is a Muggle-born Gryffindor, who becomes best friends with Harry Potter and Ron Weasley.
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Peppermint oil for headaches12/28/2023 The exact optimal dosage of peppermint is not known, and the numbers reflect a menthol content somewhere between 33-50%. Oral supplementation of peppermint oil for the purpose of gastrointestinal health and motility involves consuming anywhere between 450-750mg of the oil daily in 2-3 divided doses, and this is around 0.1-0.2mL of the oil itself per dosage. ![]() It is safe with the recommended dosages, but overconsumption of peppermint oil supplements does have a toxic level which is feasible to reach intentionally. Other possible benefits of peppermint oil include fast headache relief (which involves applying a topical solution of 10% peppermint oil to the scalp at the onset of a tension headache) and possibly a reduction in nausea when used as aromatherapy. It doesn't seem to influence other symptoms of IBS too much, but the reduction of abdominal pain is quite notable. It is known as a carminative agent (thought to relief flatulence), and it has a fair bit of evidence to supports its usage in reducing abdominal pain in persons with irritable bowel syndrome (IBS). The main medicinal role of peppermint is due to its muscle relaxing properties in the stomach and intestinal tract, and internal usage of peppermint appears to be able to speed up the early phase of digestion in the stomach while reducing colonic motility. ![]() This menthol is nontoxic at the recommended dose, but is the same menthol also found in some cigarette products. Peppermint has an oil component which appears to be its medicinal component, and this oil has a very large content of menthol which is seen as its bioactive ingredient. Peppermint ( Mentha piperita) is a plant which is a hybrid from watermint and spearmint, used initially for culinary and food manufacturing purposes but has also been used for its supposed medicinal benefits.
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Mono symptoms in adults12/28/2023 As for the one case of MS in someone who remained negative for Epstein-Barr, it is possible that person was infected after the sample was taken, but it is also true that, in diseases that are clinically defined by their symptoms, such as MS, it is highly unlikely that 100 percent of cases derive from the same cause, even if most do, Ascherio says. The risk of developing MS was 32 times greater for those who seroconverted by the third sample, compared with those who did not. Only one of the 801 people with MS had not been infected with Epstein-Barr before the disease’s onset. Thirty-five of the people who developed MS and 107 controls tested negative for EBV initially. Out of the 955 cases of MS, they were able to assemble appropriate samples for 801 individuals with the disease and 1,566 controls. Each person with MS was also matched with two randomly selected controls without MS, who were of the same age, sex, race or ethnicity, and branch of the military. The team was looking for seroconversion, or the appearance of antibodies in the blood as evidence of infection. In the new study, which is a much larger expansion of a 2010 investigation, the researchers analyzed up to three blood samples for each individual with MS: the first taken when most of the military personnel were under the age of 20, the last taken years later, before the onset of the disease, and one in between. ![]() After infection, Epstein-Barr lives on in some B cells of the immune system and the antibodies developed to fight it remain in the blood. Everyone else is infected in adolescence and young adulthood, when Epstein-Barr usually leads to infectious mononucleosis, also called “kissing disease” because it is transmitted via saliva. Much of the world’s population, especially in developing countries, is infected with Epstein-Barr very early in life without much ill effect, although the virus can lead to several rare cancers. “When the original studies were done with cigarette smoking and lung cancer, they found a 25-fold risk factor for people who smoked more than 25 cigarettes a day,” Cohen says. Cohen, who heads the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health and was not involved in the research, is cautious about claiming “cause.” He argues that it still must be shown that preventing Epstein-Barr prevents MS but agrees the results are dramatic. It’s rare to get such black-and-white results.” Robinson and Lawrence Steinman, both at Stanford University, wrote, “These findings provide compelling data that implicate EBV as the trigger for the development of MS.” Epidemiologist Alberto Ascherio, senior author of the new study, says, “The bottom line is almost: if you’re not infected with EBV, you don’t get MS. In an accompanying commentary, immunologists William H. “These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS,” the researchers wrote. The results, published on September 13 in Science, show that the risk of multiple sclerosis increased 32-fold after infection with Epstein-Barr but not after infection with other viruses. The researchers were able to compare the outcomes of those who were subsequently infected and those who were not. About 5 percent of those individuals (several hundred thousand people) were negative for Epstein-Barr when they started military service, and 955 eventually developed MS. military (the samples were taken for routine HIV testing). Chan School of Public Health and Harvard Medical School turned to what they call “an experiment of nature.” They used two decades of blood samples from more than 10 million young adults on active duty in the U.S. A randomized trial to test such a hypothesis by purposely infecting thousands of people would of course be unethical. ![]() To prove that infection with Epstein-Barr causes MS, however, a research study would have to show that people would not develop the disease if they were not first infected with the virus. In the disease, inflammation damages the myelin sheath that insulates nerve cells, ultimately disrupting signals to and from the brain and causing a variety of symptoms, from numbness and pain to paralysis. But people who contract infectious mononucleosis are at slightly increased risk of developing MS. ![]() Unlike Epstein-Barr, MS, a devastating demyelinating disease of the central nervous system, is relatively rare. Epstein-Barr virus (EBV) is the primary cause of mononucleosis and is so common that 95 percent of adults carry it. A connection between the human herpesvirus Epstein-Barr and multiple sclerosis (MS) has long been suspected but has been difficult to prove.
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Splashshopper edit categories12/28/2023 ![]() Note: Wireless sync option requires SplashShopper Desktop software (sold separately, 30 day free trial). ![]() SplashShopper is a leader in mobile list managers with over 200,000 active users worldwide. Backup and wireless sync with your PC or Mac (see details below) Share your SplashShopper lists with other usersi Assign items to multiple stores & track per-store prices Ini Manager is a powerful ini editor with many features that allows you to edit, add, import, export, browse, retrieve, modify and sort various types of ini. ![]() or SplashShopper, choose the menu, then File, then Export. Create an unlimited number of additional customizable lists The Edit button above the list of categories will open the Edit. Easily manage and synchronize lists on your iPhone or iPod Touch with the Windows or Mac OS companion software. Edit: tried it, it looks great, only one issue for me is the dialog that automatically. 10 additional prepopulated list types, including emergency items, travel checklist, wine recommendations, movie watch list, book read list, to do list, office supplies, household, gifts, music, and more Splash Shopper does this with a sortable category on each item. Extensive built-in grocery list eliminates the tedious task of typing in items Easily manage, backup, and sync lists to your PC or Mac.Īre you highly organized? Or maybe you’re looking for a way to get there? You need SplashShopper's completely updated version 3.0, the ultimate smart list manager that The NY Times calls iPhone's "Best in Productivity." Manage your lists of groceries, gifts, to do’s, wines, music, movies, and more. *****For a limited time, on sale for just 99 cents!*****(
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Buro muse dash12/28/2023 ![]() These are cool, but not as cool as character scraps. This guide doesn't talk much about elfins, you might want to look elsewhere for that topic.įor whichever character you want, it requires a bit of luck, as the character scraps are semi-random.Īdditionally, you will get pieces of illustrations a lot instead of character scraps. ( Marija the girl in black is available near the end of your conquest, which is a shame, because she's not only super cool and useful, but a total badass and is sexy af) ( Schoolgirl buro is only available from the Just as Planned DLC) If there is any specific character you want, here is a guide: It may not seem like much, but in this game, it feels like you'll have played 70-80. The higher level difficulty, the more XP towards your levels.Ī rough estimate of how much time it takes to get every character is around 7-8 hours. You want to keep a steady but not too easy pace, and going too high can be discouraging if you lose. Keep yourself to 4-6 level difficulties and never farther. Of course, it's up to you whether you want the DLC or not. You can unlock every character before you've even finished every song in the DLC. The Just as Planned DLC also can keep you playing the game. This may seem like a staggeringly impossible number, but remember, with Idol Buro you can get around 1 level every song. You should have every character unlocked around level 130. If you use Idol Buro, you can get at least 20 levels in every day, even more with DLC. To add on to this, getting every character requires a bit of dedication. These two factors can provide a new level every song you finish. ![]() Additionally, the Just as Planned DLC provides extra XP. Idol Buro provides extra XP as her ability and is great for leveling up. So you want to level up and get every character quickly. Press question mark to learn the rest of the keyboard shortcuts.
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Gitup firmaware12/28/2023 Marlin's continued existence would not be possible without them. Huge thanks are due to all the contributors who regularly patch up bugs, help direct traffic, and basically keep Marlin from falling apart. Marlin is constantly improving thanks to a huge number of contributors from all over the world bringing their specialties and talents.
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Most searched models on turbo squeed12/27/2023 ![]() ![]() It’s hard to overstate how different it feels to inspect an object using a high-end VR system like Oculus Rift or HTC Vive. If you have access to an Oculus Rift+Touch or an HTC Vive, then definitely check it out for yourself and let us know what you think. This gallery was attached as a free download to all products featured in his gallery, giving prospective buyers that ability to actually kick the tires on his models in VR prior to purchase. His creatures are imposing in a way that only VR can deliver, making Cecoaliensa the perfect choice. If you love VR, and you love zombies, then at some point one of Cecoaliensa’s creations has almost certainly shuffled from the darkness and killed you. ![]() We approached one of our favorite creature artists, Cecoaliensa, to let us feature his work in our first publicly-released VR Gallery. With the ability to grasp we decided to create a central table in the space that would allow users to pick up and inspect small-scale versions of the models that stood life-size around the perimeter. With teleportation in play we were able to expand the physical size of the space. Using Unreal’s exceptional VR Template we were ultimately able to incorporate systems like teleportation and grasp without much trouble. It was great, everyone loved it, so we continued. Models were all static and traversal was just that - if you wanted to approach a model you literally walked to it. The first full VR gallery that we set up internally was a simple 15x15 foot area for use with an HTC Vive. As heady as it may have been for us to see our models used in actual VR games, it was difficult to really scrutinize them when they were attacking us. But as far as evaluating models there was something extremely helpful about the stillness of a simple space with a few static models. Of course, we’d seen plenty of TurboSquid models in VR before, as they had been a part of many of VR’s early titles. One of the first things we did in the lab was to simply drag a few TurboSquid model into Unreal, pull on the HMD (at the time, an Oculus DK2), and see where we stood. One of the first things we explored after setting up our VR lab was the question of what characteristics made for an ideal VR model, and how best to demonstrate those characteristics to VR developers searching our catalog. More than any new technology to come down the pipe since TurboSquid’s launch seventeen years ago, we knew VR would ultimately impact just about every industry that utilizes 3D content.
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Insomniax sierra12/27/2023 ![]() Ripto captures the dragonflies, making the dragons helpless, and accidentally scatters the dragonflies across the world with a spell. ![]() The story begins with the baby dragons preparing to receive their dragonflies and celebrating. It had received mixed to negative responses from reviewers, referring to the numerous glitches, lack of storyline, originality, and long load times. In the game, Spyro must recover the stolen fireflies scattered across the Dragon Realms and foil an evil plot by Ripto and his minions.Įnter the Dragonfly is available for the PlayStation 2 and Nintendo GameCube, and was developed by Equinox Digital Entertainment and Check Six Studios. It is the sequel to Season of Ice, and introduces new features, such as the ability to breathe other elements besides fire. Season of Flame was the second Digital Eclipse title and was released for the Game Boy Advance. Spyro must use his fire breath to rescue the fairies in the various Fairy Realms after they are frozen by an evil monster named Grendor. Season of Ice was the first Spyro game not to be developed by Insomniac Games or be on a Sony console, released for the Game Boy Advance and developed by Digital Eclipse. Main articles: Spyro: Season of Ice, Spyro 2: Season of Flame, Spyro: Enter the Dragonfly, Spyro: Attack of the Rhynocs, Spyro Orange: The Cortex Conspiracy, Spyro: A Hero's Tail, and Spyro: Shadow Legacy Byrd, Bentley the Yeti, and Agent 9 the Monkey. The game also features levels in which the player controls "Sparx", Spyro's companion dragonfly, in a bird's eye view shooting game as well as four new playable characters: Sheila the Kangaroo, Sgt. ![]() As in the previous games, levels are accessed from a central home world, of which there are four: Sunrise Spring, Midday Gardens, Evening Lake, and Midnight Mountain. The rabbit hole leads to the Forgotten Realms, which are under the rule of the game's primary antagonist, The Sorceress, to whom Bianca is apprenticed. Bianca, an anthropomorphic rabbit, steals the eggs, and Spyro follows her down a rabbit hole. In the game, the dragons are celebrating the Year of the Dragon, an event held every twelve years in which new dragon eggs arrive in the dragon worlds. Year of the Dragon was released in North America on 24 October 2000 and Europe on 10 November 2000 for the PlayStation, and it was the last Spyro game to be created by Insomniac Games. Like its predecessor, it was critically acclaimed. ![]() The game introduces some abilities for Spyro, including hovering after a glide, swimming underwater, climbing ladders, head-bashing, and the ability to use power-ups. The game ends with the climatic duel between Spyro and the primary antagonist, Ripto. The structure of the game is similar to the first, with levels being accessed from the three main home worlds: Summer Forest, Autumn Plains, and Winter Tundra. The game introduced new characters including Hunter, a cheetah Elora, a faun The Professor, a mole and Zoe, a fairy. Ripto's Rage!, known as Gateway to Glimmer in Europe and Australia, followed on from the success of the first title, making its release on 2 November 1999 in North America and 5 November 1999 in Europe for the PlayStation. It received acclaim for its musical score by Stewart Copeland. The game received favorable reviews from IGN giving Spyro the Dragon a 9 out of 10. The game sold well, with a total of five million copies being sold worldwide. The game closes out with the climatic battle between Spyro and the primary antagonist, Gnasty Gnorc. Each level is accessed through 'portals' from a main world. It is a platform game that placed the player as Spyro, a small purple dragon set with the task of freeing his fellow dragons from crystal prisons, which are scattered around their world. Spyro the Dragon was released in North America on 10 September 1998 and Europe in October 1998 for the PlayStation. Main articles: Spyro the Dragon, Spyro 2: Ripto's Rage!, and Spyro: Year of the Dragon Originally published by Sony Computer Entertainment and created by Insomniac Games, the franchise has changed hands and developers numerous times before the rights to the intellectual property were acquired by Activision in 2008.Ī collection of remakes of the original Spyro PlayStation trilogy called Spyro Reignited Trilogy, developed by Toys for Bob, was released for the PlayStation 4 and Xbox One in November 2018, and later for Microsoft Windows and Nintendo Switch in September 2019. Since the series' introduction in 1998 with the PlayStation game Spyro the Dragon, there have been numerous sequels and a reboot trilogy. Spyro is a series of platform video games which features the main protagonist Spyro, a dragon.
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Ucsc cplot12/27/2023 Window, tracks within the collection will sort in order of similarity. For the given region visible in the browser To sort by similarity, right-click the collection in the browser window and select Re-order collections within the browserĭrag and drop collections (composite tracks) within the browser to rearrange the order.When viewing collections within the browser, the following viewing options are To add tracks directly from the browser, right click on the track to see options.Drag and drop to reorder tracks within a collection.A single track can be added to multiple collections, where various comparison views can be.A single track can be added/duplicated multiple times into a single collection.To the left of each track, or right-click and Delete. To remove a track from a collection, click the red "minus".Left of each track, or right-click (or select multiple, 'command + click', 'shift + click') To add a track to a collection, click the green "plus".Collections must contain subtracks that all belong to the same assembly. To add a track from a hub, load the hub first, and then select the track from 'Available.Tracks into the browser and select them from the 'Available Tracks' pane. Load external tracks: custom tracks & hub tracks.Folders below 'Visible Tracks': Lists all available tracks, regardless of.'Visible Tracks' folder: Lists tracks that are visible (not set to 'hide') in the browser.Click the small arrow to the left of folder icons to expand/contract tracks.The 'Available Tracks' top left pane displays all available graphing tracks that can be added to From the browser, right-click to configure the collection (see 'Step 3' below).Click GO (upper right) to see collections.Last save, click Discard Changes (upper right). Collection changes are saved after going to the browser window.To remove a collection: select it, right-click (or select multiple, 'command + click',.See 'Step 2' below to add/remove tracks.Once saved, double-click a collection's folder icon to edit the name, description, and.On creation, enter a name, description and optional graph color in the pop-up box.Click the Add Collection button to make a new collection.The "Collected Tracks" top right pane displays all created collections. Getting Started Step 1: Create a new collection Native tracks (tracks natively hosted by the UCSC Genome Browser).Supported tracks from the following sources can be added to a single genome browser: Only the following continuous-value graphing track types can be added to a collection: Two-minute video demo of Track Collection Builder: ![]() Track can be thought of as a container for grouping a set of similar-type annotation tracks. We are excited to be part of the Smithsonian ForestGEO network, and follow their standardized protocols.Ĭlick here to enjoy an introductory video to the FERP.The Track Collection Builder (My Data > Track Collectionīuilder) is a tool that allows multiple tracks to be copied and grouped together into one composite The Amah Mutsun Tribal Band, comprised of the descendants of indigenous people taken to missions Santa Cruz and San Juan Bautista during Spanish colonization of the Central Coast, is today working hard to restore traditional stewardship practices on these lands and heal from historical trauma. The underlying FERP monitoring data are all collected by UCSC student interns and assistants, and the FERP also serves as the site of numerous student research projects, fosering research and inquiry-based teaching about ecology and evolutionary biology in a changing world.Īs is the entire UCSC campus, the FERP is sited on the unceded territory of the Awaswas-speaking Uypi Tribe. The FERP provides exceptional opportunities for all UCSC students to learn the natural history of their campus and the tools of field-based ecological research – no prior experience is expected, and students of all backgrounds, interests, and majors are welcome. A network of litter traps and associated habitat boards provide long-term monitoring of tree flowering and fruiting and the dynamics of reptiles and amphibians. Growth, mortality, and recruitment of new stems are measured on a 5-year cycle. Oaks, tanoaks, Douglas-fir, and redwoods together comprise 3/4 of all stems. The FERP includes >40,000 tagged stems of woody trees, shrubs, and vines larger than 1 cm diameter, with 34 woody species from 30 genera and 18 families. Located on the Campus Natural Reserve of the University of California Santa Cruz campus, it is both part of an extensive area of protected forest habitat and just a short walk from the UCSC laboratories, classrooms, and residential colleges. The UCSC-FERP is a 16-ha mapped forest plot in Mediterranean-climate, mixed-evergreen coastal forest in the Santa Cruz mountains, along the Central Coast of California, USA. |